제라늄 에센셜 오일이 후각자극을 통해 식이섭취의 조절에 미치는 효과
- 제라늄 에센셜 오일이 후각자극을 통해 식이섭취의 조절에 미치는 효과
- Other Titles
- Effect of Geranium Essential Oil on Food Intake via Olfactory Stimulus
- 김용대; 최승재[최승재]; 예상백[예상백]; 나형균[나형균]; 김귀옥[김귀옥]; 배창훈; 송시연; 김용운; 박소영
- Geranium; Appetite regulation; Olfactory perception; Hypothalamus; Pro-opiomelanocortin.
- Issue Date
- 대한이비인후과학회지 두경부외과학, v.54, no.11, pp.766 - 770
- Background and Objectives Recently, obesity has become one of the major health problems in our society. To overcome this problem, keeping a balance between food intake and energy expenditure is very important. Many natural substances including essential oils have been suggested for their potential effect on reducing weight. This study was performed to evaluate whether aroma inhalation of essential oil has a role in appetite regulation and works on the central nervous system through the olfactory stimulus.
Materials and Method Food intake was measured after 30 minutes of treatment with essential oil in overnight fasted Sprague-Dawley rats. In the control group, saline was used instead of essential oil. Changes in pro-opiomelanocortin (POMC) and neuropeptide Y (NPY) mRNA expression levels in the hypothalamus were measured following 30 minutes of treatment with geranium essential oil using real-time polymerase chain reaction.
Results Of the seven essential oils, geranium significantly decreased the amount of food intake compared to the control group. Geranium essential oil significantly increased POMC mRNA expression in the hypothalamus, but did not change the NPY mRNA expression. The increased POMC mRNA expression was reversed by treatment with xylocaine, which blocks the olfactory perception.
Conclusion These results suggest that geranium essential oil has anorexic effect through the activation of POMC neurons in the hypothalamus via olfactory stimulus.
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