Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities

Title
Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities
Author(s)
남태규[남태규]구진모[구진모]Christopher Rector[Christopher Rector]최호영[최호영]Ned A. Porter[Ned A. Porter]정병선
Keywords
BREAKING PYRIDINOL ANTIOXIDANTS; ALPHA-TOCOPHEROL; VITAMIN-E; BIOLOGICAL MOLECULES; 6-AMINO-3-PYRIDINOLS; AUTOXIDATION; PEROXIDATION; REACTIVITY; RADICALS; ANALOGS
Issue Date
201112
Publisher
ROYAL SOC CHEMISTRY
Citation
ORGANIC & BIOMOLECULAR CHEMISTRY, v.9, no.24, pp.8475 - 8482
Abstract
A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.
URI
http://hdl.handle.net/YU.REPOSITORY/24221http://dx.doi.org/10.1039/c1ob05144j
ISSN
1477-0520
Appears in Collections:
약학대학 > 약학부 > Articles
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