Chemical Constituents of Cynanchum wilfordii and the Chemotaxonomy of Two Species of the Family Asclepiadacease, C. wilfordii and C. auriculatum

Title
Chemical Constituents of Cynanchum wilfordii and the Chemotaxonomy of Two Species of the Family Asclepiadacease, C. wilfordii and C. auriculatum
Author(s)
나민균강연복최현규이응박유미이종화[이종화]김도훈[김도훈]이제현[이제현]손종근이승호
Keywords
OPTICALLY ISOMERIC SUGARS; GARDENIA-JASMINOIDES; TAIWANIANUM; CONDURITOLS; GLUCOSIDES; GLYCOSIDES; CHAIN; PAIR
Issue Date
201112
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.34, no.12, pp.2021 - 2027
Abstract
Definitive identification of original plant species is important for standardizing herbal medicine. Although only the dried roots of Cynanchum wilfordii (Asclepiadaceae) are prescribed as Cynanchi Wilfordii Radix in Korean Pharmacopoeia, the roots of C. wilfordii and C. auriculatum are often misused in the Korean herbal market due to their morphological similarity and similar name. Therefore, it would be very useful to discover an effective chemical marker for the identification of the two species. To this end, we carried out a phytochemical study on the roots of C. wilfordii. As a result, twenty compounds were isolated from the roots of C. wilfordii and their chemical structures were identified as beta-sitosterol (1), wilfoside C1N (2), wilfoside C3N (3), wilfoside K1N (4), methyleugenol (5), wilfoside C1G (6), cynauriculoside A (7), daucosterol (8), 2,4-dihydroxyacetophenone (9), cynandione A (10), 2,5-dihydroxyacetophenone (11), acetovanillone (12), p-hydroxyacetophenone (13), sucrose (14), conduritol F (15), geniposide (16), succinic acid (17), 3-(beta-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione (18), bungeiside A (19), cynanoneside B (20). Among them, compounds 15, 16, 18, 19, and 20 were isolated for the first time from this species. Furthermore, conduritol F (15) was demonstrated to be contained only in C. wilfordii. Therefore, it may be useful as a chemical marker to identify the two species C. wilfordii and C. auriculatum.
URI
http://hdl.handle.net/YU.REPOSITORY/24217http://dx.doi.org/10.1007/s12272-011-1203-z
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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