Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells

Title
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells
Author(s)
나민균박지은[박지은]To Dao Cuong[To Dao Cuong]Tran Manh Hung[Tran Manh Hung]이익수[이익수]김진철[김진철]류승우[류승우]이정형[이정형]최재수[최재수]우미희[우미희]민병선[민병선]
Keywords
FACTOR-ALPHA PRODUCTION; FACTOR-KAPPA-B; NITRIC-OXIDE; EXTRACT; LIVER
Issue Date
201112
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.23, pp.6960 - 6963
Abstract
A new alkaloid, methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate (1), together with six known alkaloids, stylopine (2), protopine (3), norchelidonine (4), chelidonine (5), berberine (6), and 8-hydroxydihydrosanguinarine (7), were isolated from Chelidonium majus. Their chemical structures were primarily established using 1D and 2D NMR techniques and mass spectrometry. The anti-inflammatory activity of the isolates was examined for their inhibitory effects on LPS-induced NO production in macrophage RAW264.7 cells. Among them, compounds 5 and 7 showed strong inhibitory activities toward the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 7.3 and 4.5 mu M, respectively. In addition, compounds 5 and 7 inhibited the inductions of COX-2 and iNOS mRNA in dose-dependent manners, indicating that these compounds attenuated the syntheses of these transcripts at the transcriptional level. (C) 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24193http://dx.doi.org/10.1016/j.bmcl.2011.09.128
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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