Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway

Title
Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway
Author(s)
김화영최승희
Keywords
OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; ENZYMATIC REDUCTION; HUMAN FIBROBLASTS; OVEREXPRESSION; LOCALIZATION; EXPRESSION; RESISTANCE; INHIBITOR; MAMMALS
Issue Date
201112
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.416, no.1-2, pp.70 - 75
Abstract
MsrA is an oxidoreductase that catalyzes the stereospecific reduction of methionine-S-sulfoxide to methionine. Although MsrA is well-characterized as an antioxidant and has been implicated in the aging process and cellular senescence, its roles in cell proliferation are poorly understood. Here, we report a critical role of MsrA in normal cell proliferation and describe the regulation mechanism of cell growth by this protein. Down-regulation of MsrA inhibited cell proliferation, but MsrA overexpression did not promote it. MsrA deficiency led to an increase in p21, a major cyclin-dependent kinase inhibitor, thereby causing cell cycle arrest at the G(2)/M stage. While protein levels of p53 were not altered upon MsrA deficiency, its acetylation level was significantly elevated, which subsequently activated p21 transcription. The data suggest that MsrA is a regulator of cell growth that mediates the p53-p21 pathway. (C) 2011 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24191http://dx.doi.org/10.1016/j.bbrc.2011.10.145
ISSN
0006-291X
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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