Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults

Title
Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults
Author(s)
최혜덕김지혜[김지혜]장민정[장민정]윤여규[윤여규]신완균[신완균]
Keywords
LIPID-PEROXIDATION; ANTIOXIDANT ASTAXANTHIN; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; PLASMA; SUPPLEMENTATION; INFLAMMATION; HUMANS; CAROTENOIDS; MECHANISMS
Issue Date
201112
Publisher
WILEY-BLACKWELL
Citation
PHYTOTHERAPY RESEARCH, v.25, no.12, pp.1813 - 1818
Abstract
Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, double-blind study was performed to investigate the effect of astaxanthin (ASX), which is known to be a potent antioxidant, on oxidative stress in overweight and obese adults in Korea. Twenty-three adults with BMI > 25.0 kg/m(2) enrolled in this study and were randomly assigned to two dose groups: ASX 5 mg and 20 mg once daily for 3 weeks. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright (C) 2011 JohnWiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/24166http://dx.doi.org/10.1002/ptr.3494
ISSN
0951-418X
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약학대학 > 약학부 > Articles
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