8-아릴옥시카페인의 합성과 그 Topoisomerase II 저해활성

Title
8-아릴옥시카페인의 합성과 그 Topoisomerase II 저해활성
Other Titles
Synthesis of 8-Aryloxycaffeines and Their Inhibitory Activities on Topoisomerase II
Author(s)
장영동A. F. M 모튜어 라만[A. F. M 모튜어 라만]
Keywords
caffeine; 8-bromocaffeine; 8-aryloxycaffeine; Ullmann reaction; topoisomerase II
Issue Date
201112
Publisher
대한약학회
Citation
약 학 회 지, v.55, no.6, pp.441 - 445
Abstract
A series of 8-(substituted)aryloxy- and 8-alkyloxy-caffenines were prepared from 8-bromocaffeine and (substituted)phenols as well as alkanols by Ullmann reaction and their inhibitory activities on topoisomerase II were evaluated. A compound, 8-(quinolin-2-yl)oxycaffeine showed the strongest inhibitory activity against topoisomerase II.
URI
http://hdl.handle.net/YU.REPOSITORY/24135
ISSN
0377-9556
Appears in Collections:
약학대학 > 약학부 > Articles
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