페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성

Title
페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성
Other Titles
Synthesis and α-Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues
Author(s)
장인혜[장인혜]이은영[이은영]황보경[황보경]김인규[김인규]손경희[손경희]최란[최란]이응석우미희[우미희]손종근나영화[나영화]
Keywords
α-glucosidase; piperazine analogues; type 2 diabetes
Issue Date
201112
Publisher
대한약학회
Citation
약 학 회 지, v.55, no.6, pp.446 - 450
Abstract
As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.
URI
http://hdl.handle.net/YU.REPOSITORY/24117
ISSN
0377-9556
Appears in Collections:
약학대학 > 약학부 > Articles
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