Quantitative Analysis for the Quality Evaluation of Scutellariae Radix by HPLC/UVD

Title
Quantitative Analysis for the Quality Evaluation of Scutellariae Radix by HPLC/UVD
Author(s)
손종근정수양[정수양]문동철[문동철]손건호[손건호]민병선[민병선]우미희[우미희]
Keywords
Scutellariae Radix; Scutellaria baicalensis. HPLC-UV; Quantitative analysis
Issue Date
201112
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.4, pp.321 - 327
Abstract
In this study, quantitative analysis was developed using HPLC/UVD for the quality evaluation of Scutellariae Radix. For quantitative analysis, six major bioactive compounds were assessed. The separation conditions employed for HPLC/UVD were optimized using Phenomenex C18 column (250 ? 4.6 mm, 5 ?m) with a gradient of solvent A (1% acetic acid of H2O) and solvent B (acetonitrile : methanol : acetic acid = 70 : 30 : 1) as the mobile phase at a flow rate of 1.0 mL/min and a detection wavelength of 275 nm. These methods were fully validated with respect to linearity, accuracy, precision and recovery. The HPLC/UVD method was applied successfully to the quantification of six major compounds in the extract of Scutellariae Radix. The results indicate that the established HPLC/UVD method is suitable for the quantitative analysis and quality control of multi-components in Scutellariae Radix.
URI
http://hdl.handle.net/YU.REPOSITORY/24116
ISSN
1226-3907
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약학대학 > 약학부 > Articles
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