Systemic Review for Efficacy of Human Papillomavirus Vaccines

Title
Systemic Review for Efficacy of Human Papillomavirus Vaccines
Author(s)
박호선
Keywords
Human papillomavirus; Vaccine; Efficacy
Issue Date
201112
Publisher
대한미생물학회
Citation
Journal of Bacteriology and Virology, v.41, no.4, pp.313 - 318
Abstract
Two human papillomavirus (HPV) vaccines (Gardasil^®and Cevarix^(TM)) were launched between 2006~2007. Clinical trials have been performed in several countries. However, it takes few decades to measure HPV vaccine efficacy for the protection of cervical cancer. Therefore, several surrogate markers such as seroconversion rate, presence of HPV DNA,and cytological/ histological abnormalities have been evaluated. Until now, long-term follow-up data for 5 years (Gardasil) and for 8.4 years (Cevarix) were available from international trials. However, only seroconversion rate at 4weeks after vaccination and safety were evaluated in Korea. It is necessary to establish a reference laboratory and long-term follow-up monitoring system for the proper evaluation of HPV vaccines in Korea.
URI
http://hdl.handle.net/YU.REPOSITORY/24074
ISSN
1598-2467
Appears in Collections:
의과대학 > 미생물학교실 > Articles
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