Putative probiotic Lactobacillus spp. from porcine gastrointestinal tract inhibit transmissible gastroenteritis coronavirus and enteric bacterial pathogens

Title
Putative probiotic Lactobacillus spp. from porcine gastrointestinal tract inhibit transmissible gastroenteritis coronavirus and enteric bacterial pathogens
Author(s)
박용하서병주[서병주]문미란[문미란]김철중[김철중]레지쉬쿠마르이인선[이인선]김홍익[김홍익]
Keywords
LACTIC-ACID BACTERIA; PLANTARUM 299V; DIARRHEA; PIGS; PERFORMANCE; GROWTH; HERDS
Issue Date
201007
Publisher
SPRINGER
Citation
TROPICAL ANIMAL HEALTH AND PRODUCTION, v.42, no.8, pp.1855 - 1860
Abstract
A total of 310 bacterial strains isolated from the porcine gastrointestinal tract were tested for their activity against transmissible gastroenteritis (TGE) coronavirus and other enteric pathogens. Based on activity, the strains Probio-38 and Probio-37 were selected as potential probiotics and identified as Lactobacillus plantarum Probio-38 and Lactobacillus salivarius Probio-37 respectively by 16S rRNA gene sequencing. Supernatants of these strains inhibited TGE coronavirus in vitro in ST cells, without any cytopathic effect even after 72 h of incubation. Both the strains exhibited high survival in synthetic gastric juice. The strains were resistant to 5% porcine bile and exhibited antimicrobial activity against all the 13 enteric bacterial pathogens tested. These strains also exhibited resistance to most of the antibiotics analyzed. The inhibition of transmissible gastroenteritis coronavirus and enteric bacterial pathogens as well as the bile tolerance, high survival in gastric juice, and the antibiotic resistance indicate that the two isolated bacterial strains are ideal probiotic candidates for animal application after proper in vivo experiments.
URI
http://hdl.handle.net/YU.REPOSITORY/23943http://dx.doi.org/10.1007/s11250-010-9648-5
ISSN
0049-4747
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생명공학부 > 생명공학부 > Articles
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