Pinoresinol from the fruits of Forsythia koreana inhibits inflammatory responses in LPS-activated microglia

Title
Pinoresinol from the fruits of Forsythia koreana inhibits inflammatory responses in LPS-activated microglia
Author(s)
이승호이종구[이종구]박용기[박용기]정혜원[정혜원]Ramalingam Mahesh[Ramalingam Mahesh]김영식[김영식]
Keywords
NITRIC-OXIDE PRODUCTION; ANTIINFLAMMATORY ACTIVITY; PARKINSONS-DISEASE; LIPOPOLYSACCHARIDE; GLYCOSIDES; INDUCTION; SECRETION; SYNTHASE; EXTRACT; FRUCTUS
Issue Date
201007
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.480, no.3, pp.215 - 220
Abstract
The activation of microglia plays an important role in a variety of brain disorders by the excessive production of inflammatory mediators such as nitric oxide (NO), prostaglandin E(2) (PGE(2)) and proinflammatory cytokines. We investigated here whether pinoresinol isolated from the fruits of Forsythia koreana Nakai inhibits the inflammatory responses in LPS-activated microglia. Pinoresinol inhibited the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 in LPS-activated primary microglia. Also, pinoresinol attenuated mRNA and protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and proinflammatory cytokines in LPS-activation. However, most of these inhibitory effects of pinoresinol have been mediated by extracellular-signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) phosphorylation and the NF-kappa B dependent. The results suggest that pinoresinol attenuates inflammatory responses of microglia and could be potentially useful in modulation of inflammatory status in brain disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23931http://dx.doi.org/10.1016/j.neulet.2010.06.043
ISSN
0304-3940
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약학대학 > 약학부 > Articles
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