Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection

Title
Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to Hantaan virus infection
Author(s)
조경현김지회박현호최인호김영옥[김영옥]
Keywords
HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; HEMORRHAGIC-FEVER; HUMAN-SERUM; CIII; HYPERTRIGLYCERIDEMIA; ACYLTRANSFERASE; METABOLISM; MICE
Issue Date
201008
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.43, no.8, pp.535 - 540
Abstract
Patients with hemorrhagic fever with renal syndrome (HFRS) often exhibit altered serum lipid and lipoprotein profile during the oliguric phase of the disease. Serum lipid and lipoprotein profiles were assessed during the oliguric and recovery phases in six male patients with HFRS. In the oliguric phase of HFRS, the apolipoprotein (apo) C-III content in high-density lipoproteins (HDL) was elevated, whereas the apoA-I content was lowered. The level of expression and activity of antioxidant enzymes were severely reduced during the oliguric phase, while the cholesteryl ester transfer protein activity and protein level were unchanged between the phases. In the oliguric phase, electromobility of HDL(2) and HDL(3) was faster than in the recovery phase. Low-density lipoprotein (LDL) particle size was smaller and the distribution was less homogeneous. Patients with HFRS in the oliguric phase had severely modified lipoproteins in composition and metabolism. [BMB reports 2010; 43(8): 535-540]
URI
http://hdl.handle.net/YU.REPOSITORY/23888http://dx.doi.org/10.5483/BMBRep.2010.43.8.535
ISSN
1976-6696
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생명공학부 > 생명공학부 > Articles
이과대학 > 화학생화학부 > Articles
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