Comparative analysis of outcomes of allogeneic peripheral blood stem cell transplantation from related and unrelated donors

Title
Comparative analysis of outcomes of allogeneic peripheral blood stem cell transplantation from related and unrelated donors
Author(s)
현명수강병웅[강병웅]문준호[문준호]채의수[채의수]김종광[김종광]손상균[손상균]정주섭[정주섭]조군제[조군제]조덕현[조덕현]김여경[김여경]김형준[김형준]류헌모[류헌모]엄현석[엄현석]이상민[이상민]주영돈[주영돈]원종효[원종효]박무림[박무림]김민경
Keywords
VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; CHRONIC GRAFT; MYELOGENOUS LEUKEMIA; IDENTICAL SIBLINGS; RISK; HLA; CYCLOSPORINE; ENGRAFTMENT; MALIGNANCY
Issue Date
201008
Publisher
SPRINGER
Citation
ANNALS OF HEMATOLOGY, v.89, no.8, pp.813 - 820
Abstract
This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors, and involved 235 consecutive patients from ten centers between Jan 2004 and Dec 2008. Among these patients, 160 (68.1%) received a human leukocyte antigen-matched related PBSCT and 75 (31.9%), a matched unrelated PBSCT. The cumulative incidence of acute graft-versus-host disease (GVHD) was 43.9% for the related PBSCT and 59.3% for the unrelated PBSCT. Although the cumulative incidence of chronic GVHD was no different between the related (54.2%) and unrelated (64.9%) PBSCT, the cumulative incidence of extensive chronic GVHD was higher among the unrelated PBSCT (34.9%) than among the related PBSCT (17.0%). The overall survival rate at 4 years was 58.2% versus 49.1%, and the cumulative incidence of relapse was 28.4% versus 25.0% for the related and unrelated PBSCT, respectively. Among the factors examined, unrelated PBSCT, the CD34-positive cell count, and cytomegalovirus infection were all related with a higher incidence of extensive chronic GVHD. However, in a multivariate analysis, only unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 2.012; P value, 0.048). In conclusion, the survival and relapse incidence were not significantly different between the related and unrelated PBSCT.
URI
http://hdl.handle.net/YU.REPOSITORY/23887http://dx.doi.org/10.1007/s00277-010-0913-5
ISSN
0939-5555
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의과대학 > 내과학교실 > Articles
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