The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma

Title
The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma
Author(s)
김기홍김영식[김영식]신동훈최종수
Keywords
CALCIFYING EPITHELIOMA; MUTATIONS; CADHERIN; TUMORS; SKIN; CANCER; BENIGN
Issue Date
201008
Publisher
KOREAN DERMATOLOGICAL ASSOC
Citation
ANNALS OF DERMATOLOGY, v.22, no.3, pp.284 - 289
Abstract
Background: Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. beta-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. beta-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the beta-Catenin expression are still controversial. Objective: We wanted to evaluate the pattern and the intracellular localization of the beta-Catenin expression in pilomatricoma by performing immunohistochemical staining. Methods: Twenty-seven paraffin-embedded tissue samples that were diagnosed as pilomatricoma were immunohistochemically stained with beta-Catenin antibody. Results: Basaloid cells were found 15 samples of the total 27 pilomatricomas. All (15/15) of the basaloid cells strongly expressed beta-Catenin, but the transitional cells and the shadow cells did not. In the basaloid cells, the nuclei and membranes showed prominent beta-Catenin immunoreactivities, but the cytoplasm showed weak beta-Catenin immunoreactivity. Conclusion: This study confirmed that the nucleus and membrane of all the basaloid cells in the pilomatricomas showed a strong beta-Catenin expression, but the transitional cells and shadow cells showed negative beta-Catenin immunoreactivity. (Ann Dermatol 22(3) 284 similar to 289, 2010)
URI
http://hdl.handle.net/YU.REPOSITORY/23880http://dx.doi.org/10.5021/ad.2010.22.3.284
ISSN
1013-9087
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의과대학 > 피부과학교실 > Articles
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