Injury of the Spino-Thalamo-Cortical Pathway Is Necessary for Central Post-Stroke Pain

Title
Injury of the Spino-Thalamo-Cortical Pathway Is Necessary for Central Post-Stroke Pain
Author(s)
장성호홍지헌배대석정진영최병연장철훈김성호안상호
Keywords
TENSOR FIBER TRACKING; WHITE-MATTER; SENSORY ABNORMALITIES; BRAIN-STEM; TRACTOGRAPHY; MECHANISMS; SYSTEM; CORTEX; MRI
Issue Date
201008
Publisher
KARGER
Citation
EUROPEAN NEUROLOGY, v.64, no.3, pp.163 - 168
Abstract
Objectives: We investigated the relationship between injury of the spino-thalamo-cortical pathway (STP) and central post-stroke pain (CPSP) in patients with intracerebral hemorrhage, using diffusion tensor tractography (DTT). Methods: 30 consecutive chronic patients, in whom integrity of the STP and the medial lemnisco-thalamo-cortical pathway (MLP) were spared in both hemispheres, were recruited. We classified the patients into two groups according to the presence of the CPSP. DTTs were obtained using the FMRIB Software Library. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. A laterality index (LI) was used to determine asymmetry of DTT parameters between the hemispheres. Results: The LI for tract volume of the STP in the CPSP group was lower than that of the non-CPSP group (p = 0.000). However, there were no differences between the CPSP group and non-CPSP group for the LIs of FA or MD of the STP or for the LIs of FA, MD, or tract volume of the MLP (p > 0.05). Conclusions: Decrease of tract volume without changes in the STP FA or MD values in the CPSP group indicates partial injury of STP. Therefore, injury of the STP seems to be a requirement for the development of CPSP in patients with intracerebral hemorrhage. Copyright (c) 2010 S. Karger AG, Basel
URI
http://hdl.handle.net/YU.REPOSITORY/23879http://dx.doi.org/10.1159/000319040
ISSN
0014-3022
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 신경외과학교실 > Articles
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