Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica

Title
Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica
Author(s)
손종근정명선양주혜이응이지혜장현욱
Keywords
PLANCH ULMACEAE; MAST-CELLS; INNER BARK; GLYCOSIDES; INHIBITION; LEAVES; 5-LIPOXYGENASE; ANAPHYLAXIS; LIGNAN; CYCLOOXYGENASES-2
Issue Date
201008
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.18, no.3, pp.321 - 328
Abstract
Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated against the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin D(2) generation but also 5-lipoxygenase dependent leukotrien C(4) generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited beta-hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.
URI
http://hdl.handle.net/YU.REPOSITORY/23871http://dx.doi.org/10.4062/biomolther.2010.18.3.321
ISSN
1976-9148
Appears in Collections:
약학대학 > 약학부 > Articles
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