Composite nanofiber mats consisting of hydroxyapatite and titania for biomedical applications

Title
Composite nanofiber mats consisting of hydroxyapatite and titania for biomedical applications
Author(s)
김석영김홍미[김홍미]채원표[채원표]장기환천성수정용수[정용수]강인규[강인규]
Keywords
CELL-ADHESION; FIBER MATS; TISSUE; SCAFFOLDS; PHOSPHATE; MICROSTRUCTURE; NANOPARTICLES; BIOCERAMICS; GENERATION; COATINGS
Issue Date
201008
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v.94B, no.2, pp.380 - 387
Abstract
Composite nanofiber mats (HA/TiO(2)) consisting of hydroxyapatite (HA) and titania (TiO(2)) were fabricated via an electrospinning technique and then collagen (type I) was immobilized on the surface of the HA/TiO2 composite nanofiber mat to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite nanofiber mat (HA/TiO(2)-col) was investigated using an X-ray diffractometer, electron spectroscopy for chemical analysis, and scanning electron microscope. The potential of the HA/TiO(2)-col composite nanofiber mat for use as a bone scaffold was assessed by an experiment with osteoblastic cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation. The results showed that the HA/TiO(2)-col composite nanofiber mats possess better cell adhesion and significantly higher proliferation and differentiation than untreated HA/TiO(2) composite nanofiber mats. This result suggests that the HA/TiO(2)-col composite nanofiber mat has a high-potential for use in the field of bone regeneration and tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B: 380-387, 2010.
URI
http://hdl.handle.net/YU.REPOSITORY/23861http://dx.doi.org/10.1002/jbm.b.31664
ISSN
1552-4973
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공과대학 > 신소재공학부 > Articles
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