Novel Influenza A (H1N1) Infection in Immunocompromised Patients

Title
Novel Influenza A (H1N1) Infection in Immunocompromised Patients
Author(s)
김유경Song, Kyung Eun[Song, Kyung Eun]Seo, Kwan Yong[Seo, Kwan Yong]Lee, Hyun Chul[Lee, Hyun Chul]Lee, Won Kil[Lee, Won Kil]
Keywords
STEM-CELL TRANSPLANTATION; HEMATOLOGIC MALIGNANCIES; VIRUS-INFECTION; UNITED-STATES; RECIPIENTS; MORTALITY
Issue Date
201008
Publisher
KOREAN SOC LABORATORY MEDICINE
Citation
KOREAN JOURNAL OF LABORATORY MEDICINE, v.30, no.4, pp.388 - 393
Abstract
Background : Since April 2009, novel influenza A (H1N1) infection is spreading throughout the world. This infection might be fatal for immunocompromised patients who are at a potentially high risk of developing infectious complications. We investigated the detection rate and features of H1N1 infection in immunocompromised patients. Methods : Between August 2009 and February 2010, we examined 8,112 subjects, including 390 immunocompromised patients, for H1N1. Swab samples were taken from the nose and throat of the participants. Real-time PCR was performed to identify H1N1 viral genes. Results : Positive results were obtained in 2,953/8,112 (36.4%) subjects and 46/390 (11.8%) immunocompromised patients. H1N1 was identified in 8.7% patients with solid cancer, 12.9% patients with hematologic malignancy, 16.7% patients with chronic renal disease, and 14.5% patients with kidney transplantation. The mean cycle threshold (Ct) value of PCR was significantly lower (P<0.05) in patients with hematologic malignancy as compared to that in patients with chronic renal disease and control subjects. Four patients died due to respiratory complications. Conclusions : The detection rate of H1N1 was significantly lower in immunocompromised patients than in other patients. The Ct value of patients with hematologic malignancy was significantly lower than that of other immunocompromised patients and control subjects. (Korean J Lab Med 2010;30:388-93)
URI
http://hdl.handle.net/YU.REPOSITORY/23817http://dx.doi.org/10.3343/kjlm.2010.30.4.388
ISSN
1598-6535
Appears in Collections:
의과대학 > 진단검사의학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE