Bilateral serous retinal detachment as a presenting sign of acute lymphoblastic leukemia.

Title
Bilateral serous retinal detachment as a presenting sign of acute lymphoblastic leukemia.
Author(s)
장우혁김진선[김진선]사공민
Keywords
antineoplastic agent; acute lymphoblastic leukemia; article; case report; convalescence; eye fundus; female; fluorescence angiography; follow up; human; middle aged; optical coherence tomography; pathophysiology; physiology; retina detachment; visual acuity; Antineoplastic Agents; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recovery of Function; Retinal Detachment; Tomography, Optical Coherence; Visual Acuity
Issue Date
201008
Citation
Korean journal of ophthalmology : KJO, v.24, no.4, pp.245 - 248
Abstract
We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9x10(3)/microL with 64.6% lymphoblasts. A bone marrow aspirate revealed the presence of lymphoblasts. Cytogenetic and molecular genetic analysis detected a reciprocal translocation between chromosome 9 and 22, t(9;22) (q34;q11). A diagnosis of Ph(+) ALL was made. Following systemic chemotherapy, the bilateral SRD resolved completely with full recovery of vision. The sudden appearance of SRD should raise suspicion for leukemia. Prompt recognition of this disease is important for early systemic treatment and restoration of visual function.
URI
http://hdl.handle.net/YU.REPOSITORY/23808
ISSN
1011-8942
Appears in Collections:
의과대학 > 안과학교실 > Articles
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