Efficacy of Rifaximin Compared with Ciprofloxacin for the Treatment of Acute Infectious Diarrhea: A Randomized Controlled Multicenter Study

Title
Efficacy of Rifaximin Compared with Ciprofloxacin for the Treatment of Acute Infectious Diarrhea: A Randomized Controlled Multicenter Study
Author(s)
장병익홍경섭[홍경섭]김유선[김유선]한동수[한동수]최창환[최창환]박영숙[박영숙]이강문[이강문]이수택[이수택]김현수[김현수]김주성[김주성]
Keywords
RESISTANT ESCHERICHIA-COLI; TRAVELERS DIARRHEA; DOUBLE-BLIND; BACTERIA; MANAGEMENT; EMERGENCE; KOREA
Issue Date
201009
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v.4, no.3, pp.357 - 362
Abstract
Background/Aims: Ciprofloxacin has been widely prescribed for acute infectious diarrhea. However, the resistance to this drug is increasing. Rifaximin is a novel but poorly absorbed rifamycin derivative. This study evaluated and compared the efficacies of rifaximin and ciprofloxacin for the treatment of acute infectious diarrhea. Methods: We performed a randomized controlled multicenter study in Korea. Patients with acute diarrhea were enrolled and randomized to receive rifaximin or ciprofloxacin for 3 days. The primary efficacy endpoint was the time to last unformed stool (TLUS). Secondary endpoints were enteric wellness (reduction of at least 50% in the number of unformed stools during 24-hour postenrollment intervals), general wellness (subjective feeling of improvement), and proportion of patients with treatment failure. Results: Intent-to-treat analysis (n=143) showed no significant difference between the rifaximin and ciprofloxacin groups in the mean TLUS (36.1 hours vs 43.6 hours, p=0.163), enteric wellness (49% vs 57%, p=0.428), general wellness (67% vs 78%, p=0.189), or treatment failure rate (9% vs 12%, p=0.841). The adverse events did not differ significantly between the two groups. Conclusions: These results suggest that rifaximin is as safe and effective as ciprofloxacin in the treatment of acute infectious diarrhea. (Gut Liver 2010;4:357-362)
URI
http://hdl.handle.net/YU.REPOSITORY/23717http://dx.doi.org/10.5009/gnl.2010.4.3.357
ISSN
1976-2283
Appears in Collections:
의과대학 > 내과학교실 > Articles
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