Gentamicin-Loaded Wound Dressing With Polyvinyl Alcohol/Dextran Hydrogel: Gel Characterization and In Vivo Healing Evaluation
- Gentamicin-Loaded Wound Dressing With Polyvinyl Alcohol/Dextran Hydrogel: Gel Characterization and In Vivo Healing Evaluation
- 류원석; 황마로; 김종오; 이정훈; 김용일; 김정훈[김정훈]; 장선우[장선우]; 진성규[진성규]; 김정애; 한성수; 구세광[구세광]; 용철순; 최한곤
- POLY(VINYL ALCOHOL) HYDROGELS; POLY(ETHYLENE GLYCOL); BLENDED HYDROGEL; SODIUM ALGINATE; ELECTRON-BEAM; SKIN WOUNDS; CHITOSAN; MATRIX; FIBROBLASTS; IRRADIATION
- Issue Date
- AAPS PHARMSCITECH, v.11, no.3, pp.1092 - 1103
- To develop a gentamicin-loaded wound dressing, cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and dextran using the freezing-thawing method. Their gel properties such as gel fraction, swelling, water vapor transmission test, morphology, tensile strength, and thermal property were investigated. In vitro protein adsorption test, in vivo wound healing test, and histopathology were performed. Dextran decreased the gel fraction, maximum strength, and thermal stability of hydrogels. However, it increased the swelling ability, water vapor transmission rate, elasticity, porosity, and protein adsorption. The drug gave a little positive effect on the gel properties of hydrogels. The gentamicin-loaded wound dressing composed of 2.5% PVA, 1.13% dextran, and 0.1% drug was more swellable, flexible, and elastic than that with only PVA because of its cross-linking interaction with PVA. In particular, it could provide an adequate level of moisture and build up the exudates on the wound area. From the in vivo wound healing and histological results, this gentamicin-loaded wound dressing enhanced the healing effect more compared to conventional product because of the potential healing effect of gentamicin. Thus, this gentamicin-loaded wound dressing would be used as a potential wound dressing with excellent forming and improved healing effect in wound care.
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