Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction

Title
Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction
Author(s)
김영조이민구[이민구]정명호[정명호]안영근[안영근]채성철[채성철]허승호[허승호]홍택종[홍택종]성인환[성인환]채제건[채제건]류재영[류재영]채인호[채인호]조명찬[조명찬]배장호[배장호]라승운[라승운]김충진[김충진]최동훈[최동훈]장양수[장양수]윤정한[윤정한]정욱성[정욱성]조정관[조정관]승기배[승기배]박승정[박승정]
Keywords
CORONARY-HEART-DISEASE; RISK; EVENTS; INTERVENTION; PREVALENCE; PREVENTION; MANAGEMENT; PREDICTOR; MORTALITY; SEVERITY
Issue Date
201009
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.10, pp.1456 - 1461
Abstract
We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8 +/- 12.3 yr); group II: Non-MS (n=808, 675 men, 64.2 +/- 13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (P=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (P=0.01). The incidence of in-hospital death was higher in group I than in group II (P=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.
URI
http://hdl.handle.net/YU.REPOSITORY/23697http://dx.doi.org/10.3346/jkms.2010.25.10.1456
ISSN
1011-8934
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의과대학 > 내과학교실 > Articles
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