Anti-Listerial Compounds from Asari Radix

Title
Anti-Listerial Compounds from Asari Radix
Author(s)
나민균오준석[오준석]황인현김동춘강선철[강선철]장태수[장태수]이승호
Keywords
ANTIBACTERIAL ACTIVITY; ESSENTIAL OIL; MONOCYTOGENES; FOOD; ARISTOLOCHIACEAE; CONSTITUENTS; PATHOGENS
Issue Date
201009
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.33, no.9, pp.1339 - 1345
Abstract
Asari Radix, the roots of Asarum heterotropoides F. Maekawa var. manshuricum F. Maekawa or A. sieboldii F. Maekawa, has traditionally been used for the treatment of various infectious diseases. Since its MeOH extract inhibited the growth of Listeria monocytogenes in a preliminary test, the aim of this study was to isolate and identify the anti-listerial compounds from the plant. Activity-guided fractionation led to the isolation of seven compounds 1-7 from the MeOH extract, and their chemical structures were identified by comparison of the spectroscopic data with those in the literature. Compounds 1-7 exhibited inhibitory activity against all five tested strains of L. monocytogenes with diameter of inhibition zones ranging from 7 to 11 mm in the agar disc diffusion method. Compounds 1-3 and 7 demonstrated potent antimicrobial effects on the L. monocytogenes strains, with MICs between 62.5 and 125 mu g/mL. This is the first report that AR possesses inhibitory activity against L. monocytogenes.
URI
http://hdl.handle.net/YU.REPOSITORY/23687http://dx.doi.org/10.1007/s12272-010-0907-9
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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