Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats

Title
Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats
Author(s)
최동영Zhang Jinlu[Zhang Jinlu]Bing Guoying[Bing Guoying]
Keywords
PARKINSONS-DISEASE; AGED MICE; DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; BRAIN; ACTIVATION; MICROGLIA; LIPOPOLYSACCHARIDE; NEURODEGENERATION; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
Issue Date
201009
Publisher
ELSEVIER SCIENCE INC
Citation
NEUROBIOLOGY OF AGING, v.31, no.9, pp.1649 - 1653
Abstract
The Lewy body is a pathological hallmark of Parkinson's disease It has been revealed that the Lewy body contains nitrated alpha-synuclein which is prone to oligomerization We tested the hypothesis that aging may enhance nitration of alpha-synuclein due loan exaggerated neuroinflammatory reaction such as an excessive induction of the inducible nitric oxide synthase. which occurs post-intrapallidal lipopolysaccharide (LPS) injection Here, we show microglia activation and proinflammatory cytokine expression are more evident in the substantia nigra of elderly rats following intrapallidal LPS In addition, greater nitration of proteins like alpha-synuclein occurs in the substantia nigra of 16-month-old rats versus 3-month-old rats, which is accompanied by a higher expression level of inducible nitric oxide synthase. These results imply that an exaggerated neuroinflammatory response that occurs with aging might be involved in the increase in prevalence of neurodegenerative diseases like Parkinson's disease (C) 2008 Elsevier Inc All rights reserved
URI
http://hdl.handle.net/YU.REPOSITORY/23641http://dx.doi.org/10.1016/j.neurobiolaging.2008.09.010
ISSN
0197-4580
Appears in Collections:
약학대학 > 약학부 > Articles
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