Activation of human monocytes by a formyl peptide receptor 2-derived pepducin

Title
Activation of human monocytes by a formyl peptide receptor 2-derived pepducin
Author(s)
백석환이화영[이화영]김상두[김상두]심재웅[심재웅]김학정[김학정]권재영[권재영]김종민[김종민]박준성[박준성]배외식[배외식]
Keywords
PROTEIN-COUPLED RECEPTORS; HUMAN PHAGOCYTIC-CELLS; NF-KAPPA-B; VAL-D-MET; CHEMOTACTIC AGONIST; IMMUNE-RESPONSES; CHEMOATTRACTANT; IDENTIFICATION; FPRL1; 7-TRANSMEMBRANE
Issue Date
201009
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.584, no.18, pp.4102 - 4108
Abstract
We synthesized and investigated the effect of formyl peptide receptor 2 (FPR2)-derived pepducins in human monocytes. The FPR2-based cell-penetrating lipopeptide, "pepducin" (F2pal-16), stimulated intracellular calcium increase in human monocytes via pertussis toxin (PTX)-sensitive G-protein and phospholipase C (PLC) activity. From a functional aspect, we showed that F2pal-16 stimulated monocyte chemotaxis. F2pal-16 also stimulated the generation of superoxide anion in human monocytes. Moreover, F2pal-16 dramatically increased the production of several kinds of pro-inflammatory cytokines (CXCL8, CCL2, IL-1 beta and TNF-alpha) in human monocytes via NF-kappa B activation. Since FPR2 plays an important role in immune responses, F2pal-16 can serve as a useful reagent for the study of FPR2-mediated immune modulation. (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23632http://dx.doi.org/10.1016/j.febslet.2010.08.036
ISSN
0014-5793
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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