생약제제의 약물동태 연구 및 상호작용

Title
생약제제의 약물동태 연구 및 상호작용
Other Titles
Pharmacokinetic Studies and Drug-drug Interactions of Herbal Medicine
Author(s)
정원필[정원필]노금한[노금한]임미선[임미선]이혜원[이혜원]김은정[김은정]윤영란[윤영란]강원구
Keywords
Herbal medicine; pharmacokinetics; guidance; drug-drug interactions
Issue Date
201009
Publisher
한국임상약학회
Citation
한국임상약학회지, v.20, no.2, pp.99 - 106
Abstract
Drugs mostly represent an efficacy or an adverse effect according to their dosage and/or plasma concentrations. Therefore,to investigate the pharmacokinetic behavior of drugs including herbal medicines is necessary both to maximize the drug action and to minimize the adverse effect. To date, pharmacokinetic studies of herbal medicines have been conducted by some experts in this field on the bases of science and knowledge in Korea. On the other hand, in advanced countries, a typical series of pharmacokinetic studies has been conducted by using a harmonized guidance established. Consequently, an administrative support on these studies has to be needed in Korea as well. This study aimed to establish a draft guidance on pharmacokinetic studies of herbal medicines in non-clinical and clinical studies. Literatures previously published as well as guidances in the US, Europe and Japan were summarized for the present guidance. Effect of herbal medicines was listed on the proteins in charge of drug metabolism and transportation, as well as on the pharmacokinetics of chemical drugs. The present suggestion might be helpful to proceed pharmacokinetic studies of herbal medicines efficiently, and further polish should be needed in terms of an administrative point of view.
URI
http://hdl.handle.net/YU.REPOSITORY/23582
ISSN
1226-6051
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약학대학 > 약학부 > Articles
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