경구항진균제, Nail Lacquer 국소도포와 함께 손발톱 밑으로 항진균제를 직접 주입하여 완치를 보인 피부사상균종 (Dermatophytoma)를 동반한 손발톱진균증

Title
경구항진균제, Nail Lacquer 국소도포와 함께 손발톱 밑으로 항진균제를 직접 주입하여 완치를 보인 피부사상균종 (Dermatophytoma)를 동반한 손발톱진균증
Other Titles
Onychomycosis with Dermatophytoma Completely Cured after Treatment of Regular Subungual Application of Antifungal Solution with Systemic Antifungal Therapy and Topical Nail Laquer Application
Author(s)
김기홍신동훈최종수김영식[김영식]김미혜[김미혜]
Keywords
Complete cure; Direct subungual application; Onychomycosis
Issue Date
201009
Publisher
대한의진균학회
Citation
대한의진균학회지, v.15, no.3, pp.146 - 149
Abstract
Systemic antifungal therapy is essential to cure onychomycosis but when used alone, its complete cure rate is less than 50%. Therefore, combination therapy is preferred to achieve higher cure rate of onychomycosis, especially severely infected onychomycosis. For effective treatment of onychomycosis,it is important how antifungal agents reach causative fungi in the nail lesion. If there are dermatophytoma or onycholysis, biofilms and space may disturb antifungal agent to reach the fungi in the nail lesion. If direct antifungal solution is applied to the space, it can be spread with capillary action to the space and fungi. A 57-year old male patient presented onychomycosis with infected nail matrix and dermatophytoma,which had recurred after combination therapy of oral and topical antifungal agents before. He had been treated with subungual antifungal solution added to systemic terbinafine (250 mg/day) and amorolfine nail lacquer for initial 3 months, and with subungual antifungal solution and nail lacquer for the next 4months, and nail lacquer only for the rest period. After 3 months treatment, totally involved left great toe nail showed 50% of normal healthy nail growing from the proximal nail fold. His infected nails eventually showed complete normal nails 1 year after the initial treatment.
URI
http://hdl.handle.net/YU.REPOSITORY/23571
ISSN
1226-4709
Appears in Collections:
의과대학 > 피부과학교실 > Articles
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