Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines

Title
Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines
Author(s)
장영동홍영환[홍영환]이우진[이우진]손종근이승호김헤린[김헤린]남정민[남정민]권영주[권영주]
Keywords
ALDOL-TYPE REACTION; EVODIA-RUTAECARPA; FACILE SYNTHESIS; DERIVATIVES; ALKALOIDS; AGGREGATION; METABOLISM; INHIBITOR; MECHANISM; ANALOGS
Issue Date
201010
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.10, pp.1704 - 1709
Abstract
A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2-carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not directly related to the inhibitory activity against topoisomerases (topo) I and II. Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I.
URI
http://hdl.handle.net/YU.REPOSITORY/23517
ISSN
0918-6158
Appears in Collections:
약학대학 > 약학부 > Articles
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