Identification of Plant Extracts that Inhibit Cellular Senescence in Human Fibroblasts, Endothelial Cells, and Vascular Smooth Muscle Cells

Title
Identification of Plant Extracts that Inhibit Cellular Senescence in Human Fibroblasts, Endothelial Cells, and Vascular Smooth Muscle Cells
Author(s)
김재룡양효현[양효현]정보찬[정보찬]
Keywords
HUMAN PLATELET-AGGREGATION; HUMAN DERMAL FIBROBLASTS; CHONDROCYTE SENESCENCE; BETA-GALACTOSIDASE; SALICIS-CORTEX; ESSENTIAL OILS; DNA-DAMAGE; CONSTITUENTS; EXPRESSION; SKIN
Issue Date
201010
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.53, no.5, pp.584 - 592
Abstract
To identify plant extracts capable of inhibiting cellular senescence, the effects of plant extracts on adriamycin-induced cellular senescence in human fibroblasts, human umbilical vein endothelial cells (HUVECs), and vascular smooth muscle cells were investigated. After adriamcyin treatment, the effects of plant extracts on cellular senescence were evaluated by measuring senescence-associated beta-galactosidase activity of the cells. Among 799 plant extracts, those from Rhei Rhizoma, Cirsii Radix, and Plantagnis Semen repressed adriamycin-induced cellular senescence in fibroblasts. Extracts of Cinnamomi Cortex and Cinnamomi Cortex Spissus were effective in endothelial cells. Extracts of Euonymi Lignum Suberalatum, Salicis Radicis Cortex, Polygoni aviculari Herba, and Chaenomelis langenariae Radix reduced senescence in vascular smooth muscle cells. These results suggested the effectiveness of plant extracts in reducing cellular senescence of human cells. These plant extracts could be used to develop dietary supplements or cosmetics for modulating tissue aging or aging-associated diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/23516http://dx.doi.org/10.3839/jksabc.2010.090
ISSN
1738-2203
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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