Selective peroxisome proliferator-activated receptor delta isosteric selenium agonists as potent anti-atherogenic agents in vivo

Title
Selective peroxisome proliferator-activated receptor delta isosteric selenium agonists as potent anti-atherogenic agents in vivo
Author(s)
최혁재Jungwook Chin[Jungwook Chin]Jun Young Hong[Jun Young Hong]Jaehwan Lee[Jaehwan Lee]Hoosang Hwang[Hoosang Hwang]Hyunsil Ko[Hyunsil Ko]Dongyup Hahn[Dongyup Hahn]Jaeyoung Ko[Jaeyoung Ko]Sang-Jip Nam[Sang-Jip Nam]Jungae Tak[Jungae Tak]Jungyeob Ham[Jungyeob Ham]Heonjoong Kang[Heonjoong Kang]
Keywords
PPAR-DELTA; DRUG DESIGN; MOLECULAR MODIFICATION; COLON CARCINOGENESIS; ATHEROSCLEROSIS; CHOLESTEROL; MACROPHAGE; SULFIDES; MICE; BIOISOSTERISM
Issue Date
201010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.24, pp.7239 - 7242
Abstract
We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPAR delta-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPAR delta is a viable drug candidate for targeting and treating atherosclerosis. (C) 2010 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23469http://dx.doi.org/10.1016/j.bmcl.2010.10.103
ISSN
0960-894X
Appears in Collections:
약학대학 > 약학부 > Articles
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