Enhanced Dissolution of Coenzyme Q10 using Solid Dispersions Prepared by Low Temperature Melting Method

Title
Enhanced Dissolution of Coenzyme Q10 using Solid Dispersions Prepared by Low Temperature Melting Method
Author(s)
용철순강준혁[강준혁]엄위동[엄위동]김현찬[김현찬]이성능[이성능]최한곤[최한곤]
Keywords
Coenzyme Q10; Poloxamer 407; Solid dispersion; Solubility; Dissolution
Issue Date
201010
Publisher
한국약제학회
Citation
Journal of Pharmaceutical Investigation, v.40, no.5, pp.277 - 283
Abstract
CoQ with low melting temperature was exploited to improve its solubility by preparing its solid dispersions (SDs) with a meltable polymer, poloxamer 407 (P 407). P407 can be utilized for a relatively simple, quick, inexpensive,reproducible and potentially scalable manner in the low temperature melting method. CoQ 10 solubility and dissolution increased with increasing concentrations of P 407 in SDs. Comparison of the enhanced dissolution of CoQ 10 from different poloxamers suggested that the preparation of CoQ 10 SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its dissolution.
URI
http://hdl.handle.net/YU.REPOSITORY/23443
ISSN
2093-5552
Appears in Collections:
약학대학 > 약학부 > Articles
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