Flowers of Inula japonica Attenuate Inflammatory Responses

Title
Flowers of Inula japonica Attenuate Inflammatory Responses
Author(s)
장현욱최정현[최정현]박영나[박영나]이응[이응]김미화이지연[이지연]이윤주손종근이은경[이은경]
Keywords
Inula japonica; Inulae Flos Extract (IFE); Nitric oxide (NO); iNOS; Cytokine; NF-κB; MAP kinase
Issue Date
201010
Publisher
대한면역학회
Citation
Immune Network, v.10, no.5, pp.145 - 152
Abstract
The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inulae Flos Extract (IFE). Methods: The anti-inflammatory effects of IFE against nitric oxide (NO), PGE2, TNF-α, and IL-6 release, as well as NF-κB and MAP kinase activation were evaluated in RAW 264.7 cells. Results: IFE inhibited the production of NO and the expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. In addition, IFE reduced the release of pro-inflammatory cytokines, such as TNF-α and IL-6. Furthermore, IFE inhibited the NF-κB activation induced by LPS, which was associated with the abrogation of IκB-α degradation and subsequent decreases in nuclear p65 and p50 levels. Moreover, the phosphorylation of ERK,JNK, and p38 MAP kinases in LPS-stimulated RAW 264.7cells was suppressed by IFE in a dose-dependent manner. Conclusion: These results suggest that the anti-inflammation activities of IFE might be attributed to the inhibition of NO,iNOS and cytokine expression through the down-regulation of NF-κB activation via suppression of IκBα and MAP kinase phosphorylation in macrophages.
URI
http://hdl.handle.net/YU.REPOSITORY/23432
ISSN
1598-2629
Appears in Collections:
약학대학 > 약학부 > Articles
의과대학 > 생리학교실 > Articles
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