Flowers of Inula japonica Attenuate Inflammatory Responses
- Flowers of Inula japonica Attenuate Inflammatory Responses
- 장현욱; 최정현[최정현]; 박영나[박영나]; 이응[이응]; 김미화; 이지연[이지연]; 이윤주; 손종근; 이은경[이은경]
- Inula japonica; Inulae Flos Extract (IFE); Nitric oxide (NO); iNOS; Cytokine; NF-κB; MAP kinase
- Issue Date
- Immune Network, v.10, no.5, pp.145 - 152
- The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inulae Flos Extract (IFE).
Methods: The anti-inflammatory effects of IFE against nitric oxide (NO), PGE2, TNF-α, and IL-6 release, as well as NF-κB and MAP kinase activation were evaluated in RAW 264.7 cells. Results: IFE inhibited the production of NO and the expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. In addition, IFE reduced the release of pro-inflammatory cytokines, such as TNF-α and IL-6. Furthermore, IFE inhibited the NF-κB activation induced by LPS, which was associated with the abrogation of IκB-α degradation and subsequent decreases in nuclear p65 and p50 levels. Moreover, the phosphorylation of ERK,JNK, and p38 MAP kinases in LPS-stimulated RAW 264.7cells was suppressed by IFE in a dose-dependent manner.
Conclusion: These results suggest that the anti-inflammation activities of IFE might be attributed to the inhibition of NO,iNOS and cytokine expression through the down-regulation of NF-κB activation via suppression of IκBα and MAP kinase phosphorylation in macrophages.
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