Quantitative Analyses for the Quality Evaluation of Salviae Miltiorrhizae Radix by HPLC

Title
Quantitative Analyses for the Quality Evaluation of Salviae Miltiorrhizae Radix by HPLC
Author(s)
손종근방철[방철]문동철[문동철]손건호[손건호]민병선[민병선]우미희[우미희]
Keywords
Salviae Miltiorrhizae Radix; HPLC; Quality control
Issue Date
201010
Publisher
한국생약학회
Citation
Natural Product Sciences, v.16, no.4, pp.251 - 258
Abstract
In this study, quantitative analysis for the quality evaluation of Salviae Miltiorrhizae Radix using HPLC/UV was developed. For quantitative analysis, six major bioactive compounds were determined. The separation conditions employed for HPLC/UV were optimized using ODS C18 column (250 ? 4.6 mm, 5 mm) with gradient condition of A (1% formic acid in H2O) and B (acetonitrile : methanol : formic acid = 100 : 75 : 1) as the mobile phase at a flow rate of 1.0 mL/min and a detection wavelength of 280 nm. These methods were fully validated with respect to the linearity, accuracy, precision and recovery. The HPLC/UV method was applied successfully to the quantification of six major compounds in the Salviae Miltiorrhizae Radix. The results indicate that the established HPLC/UV method is suitable for the quantitative analysis.
URI
http://hdl.handle.net/YU.REPOSITORY/23416
ISSN
1226-3907
Appears in Collections:
약학대학 > 약학부 > Articles
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