Quantitative determination of sparfloxacin in rat plasma by liquid chromatography/tandem mass spectrometry

Title
Quantitative determination of sparfloxacin in rat plasma by liquid chromatography/tandem mass spectrometry
Author(s)
노금한[노금한]권광일[권광일]정태천강원구
Keywords
PHARMACOKINETICS; AT-4140; URINE
Issue Date
201011
Publisher
JOHN WILEY & SONS LTD
Citation
BIOMEDICAL CHROMATOGRAPHY, v.24, no.11, pp.1199 - 1202
Abstract
Sparfloxacin, a fluoroquinolone antibiotic, is used for the treatment of bacterial infection A quantification method using mass spectrometry was developed for the determination of sparfloxacin in rat plasma After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C(18) column and detected by liquid chromatography/tandem mass spectrometry with electrospray ionization The accuracy and precision of the assay were in accordance with FDA regulations for validation of bioanalytical methods This method was applied to measure the plasma sparfloxacin concentrations after a single oral administration of sparfloxacin in rats Copyright (C) 2010 John Wiley & Sons, Ltd
URI
http://hdl.handle.net/YU.REPOSITORY/23407http://dx.doi.org/10.1002/bmc.1427
ISSN
0269-3879
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE