New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae

Title
New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae
Author(s)
나민균Phi Hung Nguyen[Phi Hung Nguyen]Trong Tuan Dao[Trong Tuan Dao]Derek Tantoh Ndinteh[Derek Tantoh Ndinteh]Joseph Tanyi Mbafor[Joseph Tanyi Mbafor]박재영[박재영]정현숙[정현숙]오원근[오원근]
Keywords
ISOPRENYLATED FLAVONOIDS; INFLUENZA-VIRUS; STEM BARK; ISOFLAVANONE; ISOFLAVONES; SIGMOIDEA; AGENTS; ROOTS
Issue Date
201011
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6430 - 6434
Abstract
Influenza occurs with seasonal variations and reaches the peak prevalence in winter causing the death of many people worldwide. A few inhibitors of viral neuraminidase, including amantadine, rimantadine, zanamivir, and oseltamivir, have been used as influenza therapy. However, as drug-resistant influenza viruses are generated rapidly, there is a need to identify new agents for chemotherapy against influenza. Therefore, research on more effective drugs has been given high priority. During the course of an anti-influenza screening program on natural products, two new compounds (1 and 2) along with seven known flavonoid derivatives (3-9) were isolated as active principles from an EtOAc-soluble extract of the root bark of Erythrina addisoniae. The stilbenoid (2) and chalcone (3, 4, and 6) compounds of the isolates exhibited stronger activity than the isoflavone ones. Compound 2, which is a formylated stilbenoid derivative, exhibited strong inhibition of both influenza H1N1 and H9N2 neuraminidases with IC(50) values of 8.80 +/- 0.34 mu g/mL and 7.19 +/- 0.40 mu g/mL, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23401http://dx.doi.org/10.1016/j.bmcl.2010.09.077
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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