Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA

Title
Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA
Author(s)
Su Hui Yang[Su Hui Yang]Hue Thi My Van[Hue Thi My Van]Thanh Nguyen Le[Thanh Nguyen Le]Daulat Bikram Khadka[Daulat Bikram Khadka]조숙희[조숙희]이경태[이경태]이응석이용복[이용복]안창호[안창호]조원제[조원제]
Keywords
TOPOISOMERASE 1 INHIBITORS; CELL-CYCLE; DOCKING; 3-ARYLISOQUINOLINES; APOPTOSIS; DESIGN
Issue Date
201011
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, no.11, pp.5493 - 5497
Abstract
Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis. (C) 2010 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23366http://dx.doi.org/10.1016/j.ejmech.2010.08.042
ISSN
0223-5234
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약학대학 > 약학부 > Articles
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