Ameliorating Effects of L-Carnitine on Diabetic Podocyte Injury

Title
Ameliorating Effects of L-Carnitine on Diabetic Podocyte Injury
Author(s)
한기동판지안핑김동엽카와치 히로시[카와치 히로시]하태선[하태선]
Keywords
GENE-EXPRESSION; CELL CONTACTS; NEPHROPATHY; NEPHRIN; PROTEIN; RATS; GLUCOSE; GLOMERULOSCLEROSIS; ALPHA-ACTININ-4; CYTOSKELETON
Issue Date
201012
Publisher
MARY ANN LIEBERT INC
Citation
JOURNAL OF MEDICINAL FOOD, v.13, no.6, pp.1324 - 1330
Abstract
High glucose levels can change podocyte gene expression and subsequently induce podocyte damage through altered glucose metabolism. L-Carnitine is known to play a beneficial role in diabetes; however, there are no studies on the effects of L-carnitine on podocyte alteration under high glucose conditions. This study investigated whether L-carnitine can attenuate diabetic podocyte injury through the prevention of loss of slit diaphragm proteins. The L-carnitine treatment group showed increased glucose uptakes compared to the control group, suggesting that glucose utilization in the podocytes was increased by L-carnitine. L-Carnitine treatment also prevented decreased mRNA expressions of nephrin and podocin in the high glucose-stimulated podocytes. However, mRNA expressions of CD2AP and alpha-actinin-4 were not significantly changed by the high glucose conditions. When these data are taken together, L-carnitine can increase glucose uptake in podocytes under high glucose conditions, and its mechanism may be at least partly related to the up-regulation of nephrin and podocin. Our results help clarify the beneficial effects of L-carnitine in diabetic nephropathy.
URI
http://hdl.handle.net/YU.REPOSITORY/23289http://dx.doi.org/10.1089/jmf.2010.1079
ISSN
1096-620X
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자연자원대학 > 식품공학과 > Articles
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