Inhibitory Effects of Water Extracts of Fermented Rice Bran on Allergic Response

Title
Inhibitory Effects of Water Extracts of Fermented Rice Bran on Allergic Response
Author(s)
한기동판지안핑최경민
Keywords
NECROSIS-FACTOR-ALPHA; MAST-CELLS; RBL-2H3 CELLS; TNF-ALPHA; T-CELLS; DEGRANULATION; IL-4; EXPRESSION; INTERLEUKIN-4; EOSINOPHILS
Issue Date
201012
Publisher
SPRINGER
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.19, no.6, pp.1573 - 1578
Abstract
In this study, the effects of water extracts of fermented rice bran (FRBE) on immediate-type allergic reactions in vitro (RBL-2H3 cell line) and in vivo [ovalbumin (OVA) sensitized mice model] were investigated. FRBE inhibited beta-hexosaminidase release from RBL-2H3 cells activated by anti-dinitrophenyl (DNP) IgE while FRBE pretreatment profoundly inhibited the systemic allergic reaction induced by compound 48/80. Moreover, FRBE had a significant inhibitory effect on the mRNA expression of anti-DNP IgE-induced tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-4, 1L-6, and IL-10, all of which mediate inflammatory reactions triggered by allergic reaction. To determine the mRNA levels of cytokines in an OVA-sensitized mice model after FRBE treatment, spleen cells were harvested with several concentrations of FRBE. The FRBE-treated group showed decreased levels of TNF-alpha, IFN-gamma, IL-6, and IL-10. These results suggest that FRBE suppressed allergic and inflammatory reactions through inhibition of degranulation, histamine release, and pro-inflammatory cytokine production from mast cells.
URI
http://hdl.handle.net/YU.REPOSITORY/23279http://dx.doi.org/10.1007/s10068-010-0223-7
ISSN
1226-7708
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자연자원대학 > 식품공학과 > Articles
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