Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor kappa B and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264 7 Cells

Title
Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor kappa B and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264 7 Cells
Author(s)
장현욱유예[유예]홍태균[홍태균]김미화양주혜[양주혜]서석종박동근[박동근]고현권[고현권]서창섭[서창섭]장영채[장영채]김철호[김철호]손종근
Keywords
GENE-EXPRESSION; TRANSACTIVATION ACTIVITY; INOS EXPRESSION; MANASSANTIN-A; MMP-9; EXTRACT; CERNUUS; ROOTS; ACID; P38
Issue Date
201012
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.12, pp.1944 - 1948
Abstract
This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, Isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264 7 cells Aimed at evaluating the mechanism of action by which SG inhibits the LPS-mediated induction of MMP-9, the effects of SG on nuclear factor-kappa B (NF-kappa B) DNA binding activity, NF-kappa B-dependent reporter gene activity, inhibitory factor-kappa B (I kappa B) phosphorylation, degradation and p65 nuclear translocation were assessed SG profoundly suppressed the DNA binding activity and the reporter gene activity as well as translocation of NF-kappa B p65 subunit Furthermore, SG also dose dependently inhibited LPS-stimulated activation of mitogen-activated protein kinases (MAPKs) These findings suggest that SG may inhibit LPS-stimulated MMP-9 induction by blocking NF-kappa B and MAPKs activation
URI
http://hdl.handle.net/YU.REPOSITORY/23239http://dx.doi.org/10.1248/bpb.33.1944
ISSN
0918-6158
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약학대학 > 약학부 > Articles
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