28-Nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells

Title
28-Nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells
Author(s)
나민균Nguyen Thi Phuong Th[Nguyen Thi Phuong Th]Tran Manh Hung[Tran Manh Hung]To Dao Cuong[To Dao Cuong]김진철[김진철]김은희[김은희]진성은[진성은]이영미[이영미]김영호[김영호]최재수[최재수]민병선[민병선]
Keywords
THEACEOUS PLANTS; COMPLEX TANNINS; OLIGOGLYCOSIDES; ABSORPTION; FLOWERS; SEEDS
Issue Date
201012
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.24, pp.7435 - 7439
Abstract
Four new 28-nor-oleanane-type triterpene oligoglycosides, camellenodiol 3-O-beta-D-galactopyranosyl (1 -> 2)[beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranosyl(1 -> 3)]-beta-D-glucuronopyranoside (2), camellenodiol 3-O-4 ''-O-acetyl-beta-D-galactopyranosyl(1 -> 2)[beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranosyl(1 -> 3)] beta-D-glucuronopyranoside (4), camellenodiol 3-O-(beta-D-galactopyranosyl(1? 2)[ b-D-xylopyranosyl(1 -> 2)beta-D-galactopyranosyl(1 -> 3)]-6 '-methoxy-beta-D-glucuronopyranoside (5), and maragenin II 3-O-(b-D-galactopyranosyl(1 -> 2)[ b-D-xylopyranosyl(1 -> 2)-b-D-galactopyranosyl(1 -> 3)]-6 '-methoxy-beta-D-glucuronopyranoside (6), along with two known compounds, (1 and 3), were isolated from the stem bark of Camellia japonica. Their chemical structures were established mainly by 2D NMR techniques and mass spectrometry. The isolated compounds showed inhibitory effects on NO production in RAW264.7 macrophages. (C) 2010 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23221http://dx.doi.org/10.1016/j.bmcl.2010.10.013
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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