이엽우피소의 성분 및 멜라닌 생성 억제활성

Title
이엽우피소의 성분 및 멜라닌 생성 억제활성
Other Titles
Constituents of Cynanchum auriculatum and their Inhibitory Effect Melanogenesis in B16 Mouse Melanoma Cell Lines
Author(s)
이승호최현규강연복노은미리[노은미리]김영수[김영수]허광화나민균
Keywords
Cynanchum auriculatum; Melanogenesis; B16 cell lines; 2; 5-dihydroxyacetophenone
Issue Date
201012
Publisher
한국생약학회
Citation
생약학회지, v.41, no.4, pp.238 - 244
Abstract
Fourteen compounds were isolated from the roots of Cynanchum auriculatum and their chemical structures were identified as β-sitosterol (1), acetovanillone (2), p-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4), 2,5-dihydroxyacetophenone (5), cynandione A (6), methyleugenol (7), daucosterol (8), Succinic acid (9), cynauriculoside A (10), wilfoside C3N (11), wilfoside C1N (12), wilfoside K1N (13) and wilfoside C1G (14). Among them, compounds 2-5 were isolated from this plant for the first time. And 2, 5-dihydroxyacetophenone (5) showed the most potent inhibitory effect on melanogenesis in B-16 mouse melanoma cell lines with IC50 value of 20 µM
URI
http://hdl.handle.net/YU.REPOSITORY/23191
ISSN
0253-3073
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약학대학 > 약학부 > Articles
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