Extensive demyelinating change in cerebrum after a total knee replacement -A case report-

Title
Extensive demyelinating change in cerebrum after a total knee replacement -A case report-
Author(s)
박상진지대림변우목김승동[김승동]
Keywords
Demyelinating diseases; Hypokalemia; Osmotic myelinolysis; Total knee replacement.
Issue Date
201012
Publisher
대한마취통증의학회
Citation
Korean Journal of Anesthesiology, v.59, pp.197 - 200
Abstract
Demyelination is characterized by the loss of myelin with the preservation of axons. Demyelinating diseases can be classified into several categories: demyelination due to inflammation, viral infection, osmotic derangements and hypoxic ischemia. In particular, osmotic myelinolysis is representative, and is associated with hyperosmolality,hypokalemia or rapid correction of hyponatremia. Osmotic myelinolysis was reported to be associated with underlying conditions, such as alcoholism, diuretics and malnutrition. A 67-year-old woman with hypertension was scheduled to undergo both total knee replacements (TKR). She was observed to be lethargic with dysphagia and quadriplegia after the second TKR. She had been taking diuretics for a long time, and did not have an adequate amount of food intake due to patient controlled analgesia and a gastric ulcer after the first TKR. A laboratory examination revealed hypokalemia but normonatremia. T2 weighted-MRI revealed abnormal high signal intensity in the basal ganglia and periventricular area. This case was diagnosed with osmotic myelinolysis associated with hypokalemia without an apparent sodium imbalance.
URI
http://hdl.handle.net/YU.REPOSITORY/23161
ISSN
2005-6419
Appears in Collections:
의과대학 > 마취통증의학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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