Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Title
Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea
Author(s)
신동구김대희[김대희]오일영[오일영]이해영[이해영]김용진[김용진]김효수[김효수]김철호[김철호]오병희[오병희]김권삼[김권삼]김두일[김두일]김영대[김영대]류규형[류규형]박시훈[박시훈]백상홍[백상홍]심완주[심완주]안태훈[안태훈]오석규[오석규]이승환[이승환]이성윤[이성윤]정명호[정명호]정욱성[정욱성]정준영[정준영]최소연[최소연]최시완[최시완]현민수[현민수]
Keywords
Lacidipine; Diabetes mellitus; Hypertension; Endothelium.
Issue Date
201012
Publisher
대한심장학회
Citation
Korean Circulation Journal, v.40, no.12, pp.632 - 638
Abstract
Background and Objectives: The aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM). Subjects and Methods: This was a prospective, multicenter, open-label, single-arm study, enrolling 290 patients with mild-to-moderate hypertension and type 2 DM. Patients were initially treated with 2 mg lacidipine orally once daily for 4 weeks, which was then increased as necessary every 4 weeks to a maximal dose of 6 mg daily. The primary endpoint was the mean change in systolic blood pressure (SBP) from baseline after 12 weeks of treatment. Secondary endpoints included mean changes in diastolic blood pressure (DBP), flow-mediated vasodilatation (FMD), and serum concentrations of biochemical markers such as high-sensitivity C-reactive protein (hs-CRP), monocyte chemo-attractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1). Results: Lacidipine treatment significantly reduced SBP by -13.4±13.0 mmHg (p<0.001) and DBP by -6.2±9.3 mmHg (p<0.001). Lacidipine treatment did not improve endothelial-dependent vasodilatation, despite significantly improved nitroglycerin-induced, endothelial-independent vasodilatation. MCP-1 levels significantly decreased from 283.66±110.08 pg/mL to 257.83±100.23 pg/mL (p<0.001); whereas there were no significant changes in the levels of hs-CRP, MMP-9, or PAI-1. Conclusion: Twelve weeks of treatment with lacidipine was effective and well tolerated in mild-to-moderate hypertensive patients with type 2 DM. In spite of inducing a significant reduction in MCP-1 levels, lacidipine did not improve endothelial function.
URI
http://hdl.handle.net/YU.REPOSITORY/23157
ISSN
1738-5520
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의과대학 > 내과학교실 > Articles
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