Anti-inflammatory activity of hispidol A 25-methyl ether, a triterpenoid isolated from Ponciri Immaturus Fructus

Title
Anti-inflammatory activity of hispidol A 25-methyl ether, a triterpenoid isolated from Ponciri Immaturus Fructus
Author(s)
이승호허광화신은명[신은명]주홍유[주홍유]Irmagard Merfort[Irmagard Merfort]김영식[김영식]
Keywords
NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; TRIFOLIATA FRUIT; BACTERIAL LIPOPOLYSACCHARIDE; MOLECULAR-MECHANISMS; ENDOTHELIAL-CELLS; GENE-EXPRESSION; ACTIVATION; MACROPHAGES; SUPPRESSION
Issue Date
201001
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN JOURNAL OF PHARMACOLOGY, v.627, no.1-3, pp.318 - 324
Abstract
The anti-inflammatory activity of hispidol A 25-methyl ether (hispidol A 25-Me ether), a triterpenoid isolated from Ponciri Immaturus Fructus, was studied in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. It was revealed that hispidol A 25-Me ether dose-dependently inhibits nitric oxide (NO) production by down-regulating inducible nitric oxide synthase (iNOS). It also reduces prostaglandin E(2) (PGE(2)) production by inhibiting cyclooxygenase-2 (COX-2) expression proven on both mRNA as well as on protein levels. In addition, hispidol A 25-Me ether inhibits mRNA expressions of major pro-inflammatory cytokines including the tumor necrosis factor-alpha (TNF-alpha). interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6). Interestingly, hispidol A 25-Me ether probably exhibits a glucocorticoid-like activity, exerting functional inhibition of NF-kappa B without inhibition of DNA binging as de novo synthesis I kappa B-alpha was induced and thereby NF-kappa B activity was reduced. Furthermore, administrations of hispidol A 25-Me ether (1 and 10 mg/kg, i.p., v/w.) were tested in two animal experiments involving acute inflammation, namely, the carrageenan-induced paw edema swelling test and the acetic acid-induced vascular permeability assay, and showed concentration-related inhibitory activities. The anti-inflammatory property of hispidol A 25-Me ether seems to resemble the effects of the class of naturally occurring anti-inflammatory agents, glucocorticoids, which inhibit transcriptions of important inflammatory mediators. (C) 2009 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23049http://dx.doi.org/10.1016/j.ejphar.2009.10.036
ISSN
0014-2999
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약학대학 > 약학부 > Articles
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