2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

Title
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study
Author(s)
이응석알준바스넷[알준바스넷]프리텀다빠[프리텀다빠]라다깔끼[라다깔끼]최호영[최호영]최재훈[최재훈]윤민호[윤민호]정병선장영동나영화[나영화]조원제[조원제]권영주[권영주]이종순
Keywords
DNA-TOPOISOMERASES; SUBSTITUIERTER PYRIDINE; DERIVATIVES; COMPLEXES; 2,2'/6',2''-TERPYRIDINE; EUROPIUM(III); CANCER
Issue Date
201001
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.1, pp.42 - 47
Abstract
For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23036http://dx.doi.org/10.1016/j.bmcl.2009.11.041
ISSN
0960-894X
Appears in Collections:
약학대학 > 약학부 > Articles
이과대학 > 화학생화학부 > Articles
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