Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-alpha in Murine Lung Epithelial Cells

Title
Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-alpha in Murine Lung Epithelial Cells
Author(s)
장현욱김미화이은경[이은경]양주혜[양주혜]유예[유예]강상구장영채[장영채]이승호서석종[서석종]김철호[김철호]
Keywords
NF-KAPPA-B; TRANSCRIPTION FACTORS; AIRWAY INFLAMMATION; ENDOTHELIAL-CELLS; TYROSINE KINASE; PROTEIN-KINASE; ICAM-1; ACTIVATION; INVOLVEMENT; ASTHMA
Issue Date
201001
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.1, pp.1 - 5
Abstract
Intercellular adhesion molecule-1 (ICAM-1) is associated with processes of inflammation. We investigated the effects of deoxypodophyllotoxin (DPT) on tumor necrosis factor-alpha (TNF-alpha) induced ICAM-1 expression in the mouse lung epithelial cell line, LA4. DPT (5 to 20 nM) inhibited TNF-alpha-induced ICAM-1 expression through nuclear factor-kappa B (NF-kappa B) in a dose-dependent manner and repressed ICAM-1 promoter activity. NF-kappa B reporter gene activity and DNA binding activity were also strongly inhibited. In addition, DPT inhibited degradation by the TNF-alpha induced inhibitory kappa B-alpha (1 kappa B-alpha) in a concentration-dependent manner. Taken together with our previous results suggest DPT might provide a basis for novel anti-inflammatory drug development.
URI
http://hdl.handle.net/YU.REPOSITORY/23029
ISSN
0918-6158
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약학대학 > 약학부 > Articles
생명공학부 > 생명공학부 > Articles
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