Transglutaminase 2 expression levels regulate sensitivity to cystamine plus TRAIL-mediated apoptosis

Title
Transglutaminase 2 expression levels regulate sensitivity to cystamine plus TRAIL-mediated apoptosis
Author(s)
이태진권택규[ 권택규]박준수[박준수]장지훈[장지훈]
Keywords
BREAST-CANCER CELLS; TISSUE TRANSGLUTAMINASE; DEATH RECEPTORS; MCF-7 CELLS; RESISTANCE; SURVIVAL; INHIBITOR; INDUCTION; MELANOMA; DISEASE
Issue Date
201001
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS, v.287, no.2, pp.224 - 230
Abstract
In this study, we demonstrate for the first time that cystamine, an inhibitor of transglutaminase 2 (TG2), enhanced tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)mediated apoptosis in Caki cells, but not in normal human mesangial cells. Cystamine plus TRAIL-induced down-regulation of c-FLIP was recovered to basal levels by addition of the pancaspase inhibitor, z-VAD. The forced expression of c-FLIP attenuated cystamine plus TRAIL-mediated apoptosis in Caki cells. Although, cells expressing high levels of TG2 were more sensitive to cystamine plus TRAIL-mediated apoptosis than were cells expressing low levels of TG2, cystamine plus TRAIL-mediated apoptosis in the cell line expressing high levels of TG2 was reduced when TG2 levels were knocked down with siRNA. These results indicate that the level of TG2 modulates cystamine plus TRAIL-induced apoptosis. Taken together, the present findings suggest that cystamine may be an effective sensitizer of TRAIL-induced apoptosis in cancer cells expressing high levels of TG2. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23021http://dx.doi.org/10.1016/j.canlet.2009.06.013
ISSN
0304-3835
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의과대학 > 해부학교실 > Articles
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