Analysis of Pazufloxacin Mesilate in Human Plasma and Urine by LC with Fluorescence and UV Detection, and Its Application to Pharmacokinetic Study

Title
Analysis of Pazufloxacin Mesilate in Human Plasma and Urine by LC with Fluorescence and UV Detection, and Its Application to Pharmacokinetic Study
Author(s)
임미선Prasad B. Phapale[Prasad B. Phapale]이혜원[이혜원]김성두[김성두]Dipali D. Kale[Dipali D. Kale]이주미[이주미]박정현[박정현]문성옥[문성옥]윤영란[윤영란]
Issue Date
201001
Publisher
VIEWEG
Citation
CHROMATOGRAPHIA, v.71, no.1-2, pp.101 - 106
Abstract
A liquid chromatographic method for analysis of pazufloxacin mesilate in human plasma and urine has been developed and validated for selectivity, sensitivity, accuracy, precision, and stability in pharmacokinetic analysis. The sensitivity of the method was 0.02 mu g mL(-1) in plasma and 0.5 mu g mL(-1) in urine, with overall intra-day and inter-day precision (RSD < 10%) and accuracy (90-120%) acceptable for clinical pharmacokinetic analysis. Recovery from plasma and urine was 80-110% for both pazufloxacin mesilate and enoxacin, the internal standard. Pazufloxacin was stable in both plasma and urine, with no significant degradation under four different conditions. The method was successfully used in a preliminary study of the bioavailability of pazufloxacin mesilate in healthy human volunteers after intravenous administration of 300 and 500 mg.
URI
http://hdl.handle.net/YU.REPOSITORY/23010http://dx.doi.org/10.1365/s10337-009-1408-1
ISSN
0009-5893
Appears in Collections:
약학대학 > 약학부 > Articles
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