Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro

Title
Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro
Author(s)
나민균Quan Cheng Chen[Quan Cheng Chen]Wei Yun Zhang[Wei Yun Zhang]Wenyi Jin[Wenyi Jin]이익수[이익수]민병선[민병선]정현주[정현주]이상명[이상명]배기환[배기환]
Keywords
ISOLATED RAT ADIPOCYTES; DIABETES-MELLITUS; CELLS; TRANSLOCATION; CONSTITUENTS; TRANSPORTER; QUERCETIN; MYRICETIN; JAPONICA; INHIBIT
Issue Date
201001
Publisher
GEORG THIEME VERLAG KG
Citation
PLANTA MEDICA, v.76, no.1, pp.79 - 81
Abstract
Glucose uptake assay-guided fractionations on the methanol extract of Sophorae Flos led to the isolation of the flavonoids rutin (1), narcissin (2), quercetin (3), tamarixetin (4), and kaempferol (5) and the isoflavonoids cajanin (6), genistein (7), orobol (8), and pratensein (9). Among them, 1, 4, 5, 6, 8, and 9 significantly improved basal glucose uptake in HepG2 cells. Their improving effects were concentration dependent. Compounds 4, 5, 6, and 9 exhibited effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. However, 2, 3, and 7 did not show any improving effects. Stimulating glucose uptake into peripheral cells may be responsible for reducing the level of blood glucose in the circulation. Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs.
URI
http://hdl.handle.net/YU.REPOSITORY/23007http://dx.doi.org/10.1055/s-0029-1185944
ISSN
0032-0943
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약학대학 > 약학부 > Articles
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